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Best Heartworm Prevention For Dogs in 2020 – Reviews

There are so many illnesses our dogs can pick up but thankfully, heartworm is preventable. This is only when you get your dog the right product that can genuinely help them from catching this potentially fatal disease. Spread through the bite of a mosquito it is easily caught, but some products help to prevent such a bite from happening.

There are different ways heartworm prevention for dogs can be administered but some are more effective than others. This is why we have created our list of the top heartworm preventions for dogs so you can take steps to protect your furry friend. The time they last vary depending on the brand but each one is reliable and worth considering.

List of the Best Heartworm Prevention For Dogs

Editor’s Choice: VECTRA 3D Purple for Dogs 56-95 Lbs – 6 Doses

Easy to administer and proven to be effective, this is the best heartworm prevention for dogs. Because it repels mosquitoes, it significantly decreases your dog’s chances of being bitten. Not only does it repel them but it kills them as well as fleas, ticks, lice, sand flies, and more. Also, they die on contact so they do not have to bite to perish.

The waterproof formula means it will still be actively protecting your dog even after baths or splashing around in a river and it can be used on puppies from 8 weeks of age. Your dog gets a month’s worth of protection and although this isn’t the longest, it is one of the most reliable. It is available in 4 sizes that depend on the breed and age of your dog but you get 6 doses in this value pack and each one is super easy to apply in a way that wont upset your dog.


  • Repels mosquitoes as well as fleas, ticks, lice, and more
  • Waterproof
  • Works for a month
  • Available in different sizes


Best Natural: Wondercide Natural Products – Flea, Tick and Mosquito Control for Dogs

This is one of the best natural heartworm prevention for dogs and it comes in a large 16 oz spray bottle. This is useful as you can also use it around your home to rid it of fleas and lice but in terms of heartworm, it repels them from your dog’s coat when sprayed. It uses natural essential oils making it safe to spray because there are no harsh chemicals included. The formula is still gentle enough to use on small dogs and cats but powerful enough to rid your home of 98% – 100% of mosquitoes, fleas, and ticks.

You do need to reapply every 2 – 3 days and one issue some dog owners had is that their dog did not enjoy being sprayed for a lot of people, their pets got used to it.


  • 100% natural heartworm prevention
  • Fine to use on small dogs and cats
  • Made form essential oils
  • Gets rid of 98% of mosquitoes, fleas, and ticks

  • Have to reapply every 2-3 days

Best For Small Dogs: Bayer Animal Health K9 Advantix II Small Dog 4-Pack

This is the best heartworm prevention for dogs of 4 – 10 lbs and it is waterproof so you pooch can splash or bathe and it will still work to repel mosquitoes. You get 4 tabs in a pack and each one repels and kills mosquitoes for up to 4 weeks. It also kills fleas within 12 hours of being applied and continues to do so for a month.

Because it is easy to administer you can be confident in its ability to protect your dog from bites so heartworm is just one disease you can protect your small pooch from. Fleas and ticks are repelled and killed upon impact and it can be used on small dogs of 8 weeks and over.


  • Waterproof
  • 4 in a pack
  • Repels and kills mosquitoes for up to 4 weeks
  • Easy to administer

  • Premium brands command a premium price

Best Affordable: TevraPet Activate II Flea and Tick Prevention for Dogs

Available in different sizes depending on your dog’s age and breed this is one of the most reliable heartworm preventions for dogs. It does not require nasties to bite to kill them and it repels mosquitoes but also fleas and ticks. There is a 4-month supply and it is also waterproof so you don’t have to worry about your dog in the rain. Made in the USA, it is vet formulated for added strength and many dog owners have reported an instant difference when it comes to ticks and fleas so it is easy to see that it works.

It is more affordable than a vet bill which is why so many people have trusted it to protect their dogs.


  • Made in the USA
  • Repels and kills mosquitoes, fleas, and ticks
  • Vet formulated

  • Some dog owners reported that fleas came back faster than they anticipated

Best Value: Bayer K9 Advantix II Flea, Tick, and Mosquito Protection

For dogs of 21 – 55 lbs this is one of the better heartworm prevention for dogs. The reputable Bayer brand is behind some of the industry’s best mosquito prevention products and the pests don’t have to bite before they die which is good news for your pooch.

Each application lasts 30 days and starts working within 12 hours to protect your dog from heartworm disease. In this pack, you get a 6 month supply which means you are less likely to have to wait between applications. Recommended by vets and able to prevent biting flies, chewing lice, fleas, ticks, mosquitoes, and more, it is available in smaller pack sizes although there is a lot of value to be had in this version.


  • Works within 12 hours
  • Lasts for 30 days
  • 6 month supply
  • Kills mosquitoes upon contact

  • Some dogs can have a reaction to this product although this is rare

Best Collar: Rolf Club 3D FLEA Collar for Dogs

With 6 months worth of protection from mosquitoes, ticks, fleas, and more, this is the best dog collar heartworm protection for dogs. It works within 24 – 48 hours of being applied and is an easy way of ensuring your pooch is protected for a long time. There is no strange smell and it is completely safe to use, this version is for medium dogs.

What makes it different from other collars is that it is available in other sizes and it is completely waterproof. You need to fit it tight against the dog’s neck for it to be effective but once it has been tightened you can cut and discard any excess.


  • Works for 6 months
  • Scentless
  • Waterproof

  • Other products can be more effective
Heartworm Prevention For Dogs Guide

There are certain things we can protect our pets from and heartworm is one of the most serious diseases to avoid. Potentially fatal and transferred through the bite of a Mosquito, your pooch can benefit from a quality heartworm protection for dogs. Most products are designed to rid your furry friend of fleas and ticks yet double up as a mozzie repellent. 

Still, not all products are as effective as you might like which is why we have created the following buyer’s guide. At the end of it, you’ll know everything you need to so you can make a sensible purchase and protect your dog.

What To Look For In Heartworm Prevention For Dogs 

Easy Administration

Being able to apply the heartworm prevention for dogs is part of the battle for some people. A nervous pet might be reluctant to sit still if you use a spray which is why the tab form or a collar is a good option. These tend to last longer as well as a spray needs to be reapplied every 2-3 days in most cases.

Universal Protection

Not only will your heartworm prevention for dogs protect against mosquito bites, but many of them are great for getting rid of lice, fleas, ticks, biting flies, and more. This makes it easy for you to protect against some of the potentially dangerous infections, as well as the irritating bites of the likes of ticks.

The Active Ingredient(s)

Although the active ingredients differ from product to product, you should check to see how likely side effects are before using it. Most side effects are rare but it is always a good idea to do a little research before you apply it.

Waterproof Protection

Because most heartworm prevention for dogs lasts around a month, the product you choose needs to be waterproof. There is no predicting what your dog will get up to over the course of the next 30 days and you should not have to neglect their regular bathtime. The best products are those that stay active to protect your dog, even after a splash around.

How Long It Lasts

Some products only last a couple of days – these are usually the spray type heartworm prevention, but the best products are those that give ongoing protection. Around 30 days should be the minimum amount of protection which is less stressful on your dog and something you don’t have to remember to do every day.

Fast working Protection

Some products take a little longer to protect your dog from heartworm disease, most notably the collar types that take a day or two. The spot application products tend to work within a matter of hours which means you can let your dog outside with the confidence that they are protected.

What Are Heartworms?

Heartworm is a parasite that can be transferred via a mosquito bite which is why heartworm prevention tends to be in the form of a mosquito repellent. It spreads through the body via the lungs or heart, attacking vital organs along the way.

It is more common in dogs although cats and ferrets are two of the other common victims of heartworm disease.

How Much Does Heartworm Prevention For Dogs Cost?

Depending on what product you purchase, heartworm prevention doesn’t have to cost a lot. Most applications tend to last around a month and are bought in packs of 3 or 6. This means for around $25 – $50 you can protect your dog from this disease (and other nasties) for months before you need to consider repurchasing.

What Are The Possible Side Effects Of Using Heartworm Prevention?

Although all heartworm prevention for dogs is safe to use, it is not uncommon for some to suffer from side effects as a result of the application. Because your dog may not have been exposed to some of the active ingredients before, such a reaction might be unexpected.

It is always a good idea to keep an eye on your dog after applying the heartworm prevention and lookout for some of the common signs of side effects such as the following:

  • Diarrhea
  • Excessive drooling
  • Weakness
  • Lethargy
  • Loss of appetite
  • Irritable behavior
  • Dehydration
  • Vomiting
  • Temporary blindness

Because these side effects can be upsetting to see and some are more serious than others, it is always a good idea to consult your vet before you administer the heartworm prevention.

How To Choose The Right Heartworm Prevention For Dogs

Most products come in different strengths which make them appropriate for different breeds. The size and weight of your dog need to be considered before you buy heartworm prevention. 

If you buy the wrong strength you risk buying a product that is ineffective for a larger dog, or potentially dangerous for smaller breeds. 

How Many Dogs Get Heartworm Disease Every Year?

Approximately 250,000 dogs get heartworm disease every year. On a global scale, this still sounds like a lot which is why so many people opt for the best heartworm prevention for dogs. 

Can Garlic Prevent Heartworm In Dogs?

Home remedies can be effective but be wary of giving your dog garlic to prevent heartworm. For a start, it is not as effective as the prevention remedies we have recommended but also, excessive amounts of garlic can be toxic to a dog.

Does Heartworm Go Away On Its Own?

Once it has been injected via the mosquitoes bite, a heartworm can grow up to 10 inches long in your dog. They do not leave your dog via their stools, nor do they dissolve and they can live in a dog’s heart for several years. 

This is why it is important to use quality heartworm prevention for dogs so your dog doesn’t have to suffer the discomfort. The side effects that come as a result of medicine used to rid your dog of heartworm can cause side effects and can cause your furry friend some pain.


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